Endocrine Abstracts

The relationship between gestational diabetes mellitus (GDM) and oxidative stress is not well known and the effect of oxidative stress in GDM placenta and the impact that could have on perinatal morbidity and risk of future complications is also yet to be elucidated. The aim of the study was to evaluate the relationships between maternal and placental tissue levels of markers of oxidative stress and antioxidants in women with GDM, which potentially may have considerable clinic...

Introduction: Diabetic ketoacidosis (DKA) remains a life threatening complication in type 1 diabetes. Appropiate initial management is crucial in the evolution of this complex condition, and mistakes in the treatment are not uncommon.Medical simulation technology is a powerful tool for training physicians but papers dealing with DKA simulators are scarce.We introduce a new simulator designed in our institution aimed to junior docto...

Introduction: The adrenal ganglioneuroma are rare, benign and well differentiated tumors that arise from neural crest tissue. Most patients with adrenal ganglioneuroma are asymptomatic, and most of these are non-secreting tumors. They are usually found incidentally on abdominal imaging study for another reason.Case: A 53-year-old female, with a history of hypertension diagnosed at age 30, dyslipidaemia, depressive disorder and hysterectomy for uterine pr...

Introduction: Adrenocortical carcinoma (ACC) is a rare disease, with a severely adverse prognosis. Clinical reports, even when including a limited number of cases, can contribute to its knowledge. This study aims to characterize patients followed at our department between 1991 and 2013.Methods: Retrospective analysis of the clinical records of patients with pathological confirmation of ACC. Statistical analysis: SPSS21.Results: 22 ...

Introduction: Graves’ disease (GD) is the most common cause of hyperthyroidism in children. Therapeutic options available (anti-thyroid drugs, radioactive iodide, and thyroidectomy) are associated with complications and treatment of this age group remains controversial.Objective: To review our experience in the management of pediatric patients with GD.Materials and methods: Retrospective review of 35 children, diagnosed betwee...

Introduction: The metabolic consequences of hyperprolactinemia and the repercussions of its treatment with dopaminergic agonists are not yet fully understood. This study aims to evaluate the metabolic profile of patients with prolactinomas (prevalence of diabetes mellitus, dyslipidaemia and obesity) and identify the potential variations after treatment with bromocriptine.Methods: Retrospective study of patients followed between 1962 and 2013. Included 17...

Background and objectives: The finding of a thyroid nodule is a very common occurrence in clinical practice. Management of thyroid nodules requires a multidisciplinary approach that may be eased by a high-resolution thyroid nodule clinic. We report our clinical experience and outcomes in a high-resolution thyroid nodule clinic.Materials and methods: We conducted a retrospective analysis of 1674 thyroid nodules evaluated in a high-resolution clinic from a...

Context: Adrenocortical carcinoma (ACC) are endocrine malignant neoplasms associated with severe aggressiveness. Tumour-related glucocorticoid excess occurs in 60% of patients and is associated with poor prognosis. First clinical trials using immune checkpoint inhibitors are quite unsatisfactory and treatment advancements are urgently needed.Recently, we characterized tumour-infiltrating lymphocytes (TILs) in ACC and identified the detrimental dependency...

Adrenocortical carcinoma (ACC) is a rare malignancy with heterogeneous but dismal prognosis and despite numerous efforts to improve patient care, effective treatment options are still lacking. ACC in vitro research faces for decades one major obstacle - the unavailability of different ACC cell line models. Here, we present a newly established human ACC cell line that was directly transferred to and now proliferates in cell culture. JIL-O cell line was derived from a p...

Introduction: Glycemic variability (GV) is emerging as a measure of glycemic control in type 1 diabetic patients (T1DM) given that it provides an integrated picture of postprandial hyperglycemia and hypoglycemic episodes and is associated with diabetic complications and mortality. However, little is known about the best way to address this problem in clinical practice.Aim: To characterize GV in T1DM patients followed in our center and to identify clinica...